Dr. Jesper Haeggström’s research is focused on eicosanoids, particularly the leukotrienes (LT) that are involved in a number of inflammatory and allergic diseases, in particular asthma, rheumatoid arthritis, and arteriosclerosis.  He and his group investigate the biosynthetic and regulatory mechanisms involved in leukotriene formation at a cellular, enzyme, and genetic level with particular emphasis on 5-lipoxygenase (5-LO), LTA₄ hydrolase (LTA4H) and LTC₄ synthase (LTC4S).  These three enzymes catalyze the key steps in the biosynthesis of the proinflammatory compounds LTB₄ and LTC₄.

Visit Dr. Haeggstrom’s laboratory.