Dr. Krishnarao Maddipati is primarily interested in evaluating the role of bioactive lipids, especially metabolites of polyunsaturated fatty acids, in inflammation and unalamation (un-ala-mation; maintenance of homeostasis from lipid mediator balance). These include metabolites of ω-6 and ω-3 fatty acids by all three major pathways of PUFA metabolism, viz., Cyclooxygenase, Lipoxygenase, and the Cytochrome P450. Identification of lipid biomarkers in cancer and inflammatory diseases by LC-MS and identification of anticancer and anti-inflammatory compounds in dietary ingredients to provide a biochemical rationale for their beneficial effects are other areas of research interest to his group.